June 24, 2010
Where do you search for exotic variants of a particular GPCR? How do you identify natural sequence variants of a particular receptor? And how about matching a receptor with a particular synthetic ligand, or the other way around? This is where I'd start:
- IUPHAR Database Comprehensive listing of GPCRs with information related to genes and ligands that bind particular receptors; listed chronologically with receptor/ligand pairings.
- GLIDA: GPCR-Ligand Database Information on GPCRs and their known ligands. Start search with either GPCR or ligand. Last entry: 10/10/2009.
- GPCRDB A comprehensive, sequence focused information system for G protein-coupled receptors. Browse GPCR families interactively, create web-based blast, alignments and predict the effect of point mutations.
- gpDB A database of GPCRs, G-proteins, Effectors and their interactions. Last update: 20/03/2008.
- Endogenous GPCRs in common cell lines Useful for double-checking heterologous receptor expression.
- GPCR Natural Variants Database Describes sequence variants of GPCRs in humans.
- GPCR Pattern Recognition Tool to query a sequence against ca. 120 GPCR fingerprints
- SEVENS GPCR gene information on a genomic scale.
Are there any other databases or online resources that should be included here?
Thanks! And a special thanks to the curators of these useful GPCR database tools.