β2 Adrenergic Receptor
| Structure Notes | PDB | Resolution [A] | Reference |
|---|---|---|---|
| b2AR365-Fab5 complex | 2R4S, 2R4R | 3.4 / 3.4 | Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, & Kobilka BK (2007). Crystal structure of the human β2 adrenergic G-protein-coupled receptor. Nature 450:383-387. |
| Complex with Carazolol ligand and bound Cholesterol; T4 lysozyme fusion in 3rd intracellular loop | 2RH1 | 2.4 | Cherezov et al. (2007). High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor. Science 318:1258-1265 |
| T4 lysozyme fusion in 3rd intracellular loop, bound cholesterol | 3D4S | 2.8 | Hanson et al., (2008) A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure 16: 897-905 |
| methylated receptor | 3KJ6 | 3.4 | Bokoch et al., (2010) Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. (2010) Nature 463: 108-112 |
| T4 lysozyme fusion in 3rd intracellular loop, bound cholesterol, mutations: E122W, N187E, C1054T, C1097A; inverse agonist ICI 118,551 | 3NY8 | 2.84 | To be Published: Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551 |
| T4 lysozyme fusion in 3rd intracellular loop, bound cholesterol, mutations: E122W, N187E, C1054T, C1097A; Timolol | 3NY9 | 2.48 | To be published: Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist |
| T4 lysozyme fusion in 3rd intracellular loop, bound cholesterol, mutations: E122W, N187E, C1054T, C1097A; antagonist alprenolol | 3NYA | 3.16 | Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography |
| agonist-occupied β2 adrenergic receptor (active) in complex with the (nucleotide free) Gs heterotrimer | 3SN6 | 3.2 | Rasmussen et al. Crystal structure of the β2 adrenergic receptor–Gs protein complex Nature (2011) |