Rhodopsin
| Structure Notes | PDB | Resolution [A] | Reference |
|---|---|---|---|
| first experimental GPCR structures | 1F88, 1HZX | 2.8 | Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M. Science. 2000 Aug Crystal structure of rhodopsin: A G protein-coupled receptor. 4;289(5480):739-45. Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry. 2001 Jul 3;40(26):7761-72. |
| shows functional water molecules | 1L9H | 2.6 | Okada T, Fujiyoshi Y, Silow M, Navarro J, Landau EM, Shichida Y. Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5982-7. Epub 2002 Apr 23. |
| focus on retinal conformation | 1U19 | 2.2 | Okada T, Sugihara M, Bondar AN, Elstner M, Entel P, Buss V. The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J Mol Biol. 2004 Sep 10;342(2):571-83. |
| Thermostable N2C/D282C mutant heterologously expressed in COS cells | 2J4Y | 3.4 | Standfuss J, Xie G, Edwards PC, Burghammer M, Oprian DD, Schertler GF. Crystal structure of a thermally stable rhodopsin mutant. J Mol Biol. 2007 Oct 5;372(5):1179-88. Epub 2007 Mar 12. |
| photoactivated and ground state | 2I35, 2I36, 2I37 | 3.8, 4.1, 4.15 | Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23 |
| Retinal removed: Opsin | 3CAP | 2.9 | Park JH, Scheerer P, Hofmann KP, Choe HW, Ernst OP. Nature. 2008 Jul 10;454(7201):183-7. Epub 2008 Jun 18. Crystal structure of the ligand-free G-protein-coupled receptor opsin. |
| activated form of Ops*-GalphaCT peptide complex | 3DQB | 3.2 | Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP. Crystal structure of opsin in its G-protein-interacting conformation. Nature. 2008 Sep 25;455(7212):497-502. |
| Squid Rhodopsin | 2Z73 | 2.5 | Murakami M, Kouyama T. Crystal structure of squid rhodopsin. Nature. 2008 May 15;453(7193):363-7. |