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	<title>News</title>
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	<dc:language>en</dc:language>
	<dc:creator>mcanady@comprendia.com</dc:creator>
	<dc:rights>Copyright 2011</dc:rights>
	<dc:date>2011-04-08T15:41:31+00:00</dc:date>
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	  <title>Gilead Sciences Selects Emerald BioStructures for Crystallization Studies of a Novel Membrane Protein Target</title>
	  <link>http://www.emeraldbiostructures.com//news/gilead_sciences_emerald_biostructures_membrane_protein_drug_discovery</link>
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	BAINBRIDGE ISLAND, WA. January 31, 2012. Gilead Sciences, Inc. (Foster City, CA) and Emerald BioStructures, Inc. have launched a collaboration to crystallize a novel integral membrane protein drug target.&nbsp; The structural studies will support Gilead&rsquo;s efforts to use structural insights to support drug discovery for this challenging class of targets.&nbsp; The project will make use of Emerald&rsquo;s high throughput crystallization platform and specialized membrane protein crystallization tool set and includes a technology transfer component.&nbsp;<br />
	&nbsp;<br />
	<strong>About Emerald BioStructures&nbsp;</strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br />
	Emerald BioStructures is an integrated gene-to-structure contract research organization that provides collaborative drug discovery services to pharmaceutical companies, biotechnology companies, academic institutions, and government facilities. Emerald has extensive expertise in the engineered expression, protein production and crystal structure determination of GPCRs and integral membrane proteins. The company operates a high-throughput platform leveraged for fragment-based lead discovery and structure-based drug design. Emerald&rsquo;s work provides a solid foundation for the discovery of highly selective, efficacious drugs. www.emeraldbiostructures.com</p>
<p>
	<strong>About Gilead Sciences</strong><br />
	Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. Gilead&rsquo;s mission is to advance the care of patients suffering from life-threatening diseases worldwide. Headquartered in Foster City, California, Gilead has operations in North America, Europe and Asia Pacific.</p>
<p>
	<strong>Emerald BioStructures Contact:</strong><br />
	Emerald BioStructures: Diana Wetmore, VP of Business Development &amp; Alliances (206) 780-8959, <a href="mailto:dwetmore@embios.com">dwetmore@embios.com</a></p>
<p>
	<strong>For Media:</strong><br />
	Mary Canady, Comprendia LLC<br />
	<a href="mailto:mcanady@comprendia.com">mcanady@comprendia.com</a></p>

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	  <dc:subject></dc:subject>
	  <dc:date>2012-01-31T20:31:13+00:00</dc:date>
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	  <title>Heptares Therapeutics and Emerald BioStructures Build Their GPCR Structure Collaboration</title>
	  <link>http://www.emeraldbiostructures.com//news/heptares_therapeutics_and_emerald_biostructures_build_their_gpcr_structure</link>
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	Heptares Therapeutics and Emerald BioStructures, leaders in G-protein-coupled receptor (GPCR) structural biology, recently expanded their agreement aimed at combining their expertise to enable Heptares&rsquo; discovery of new therapies for this important family of drug targets. GPCRs are the target of 25-30% of all drugs, but have remained recalcitrant to structure based drug discovery due to their association with cell membranes. Heptares and Emerald began working together on these difficult targets in February 2010. In this FTE-based agreement, the two companies will work together using protein engineering, purification studies, and crystallization optimization to aid active GPCR structural studies. Heptares&rsquo; STaRS&reg; GPCR stabilizing technology will be complemented by Emerald&rsquo;s expression platform and depth of experience with the crystallization of membrane proteins.</p>
<p>
	<strong>About Emerald BioStructures&nbsp;</strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br />
	Emerald BioStructures is an integrated gene-to-structure contract research organization that provides collaborative drug discovery services to pharmaceutical companies, biotechnology companies, academic institutions, and government facilities. The company operates a high-throughput platform leveraged for fragment-based lead discovery, structure-based drug design, and elucidation of antibody-antigen structures. Emerald&rsquo;s work provides a solid foundation for the discovery of highly selective, efficacious drugs. <a href="http://www.emeraldbiostructures.com">www.emeraldbiostructures.com</a></p>
<p>
	<strong>About Heptares</strong><br />
	Heptares is a drug discovery company creating new medicines targeting G-protein-coupled receptors (GPCRs). The company is currently leveraging its GPCR expertise and proprietary StaR&reg; technology to build a pipeline of best-in-class and first-in-class GPCR-targeted medicines for the treatment of CNS, metabolic and other diseases. <a href="http://www.heptares.com">www.heptares.com</a></p>
<p>
	Emerald BioStructures Contact:<br />
	Emerald BioStructures: Diana Wetmore, VP of Business Development &amp; Alliances (206) 780-8959, <a href="mailto:dwetmore@embios.com">dwetmore@embios.com</a></p>
<p>
	&nbsp;</p>

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	  <dc:subject></dc:subject>
	  <dc:date>2011-12-06T19:29:51+00:00</dc:date>
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	<item>
	  <title>Emerald BioStructures and UCB Announce Multi&#45;year Extension of Structure&#45;Based Drug Discovery Collaboration for Multiple Targets</title>
	  <link>http://www.emeraldbiostructures.com//news/emerald_biostructures_and_ucb_announce_multi_year_extension</link>
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	<strong>Emerald to Apply Fragment Screening and Structural Biology Expertise to Support UCB Pipeline</strong></p>
<p>
	BAINBRIDGE ISLAND, Wash.--(BUSINESS WIRE - October 26, 2011)--Emerald BioStructures today announced a three-year extension of its ongoing collaboration with <a href="http://www.ucb.com/">UCB</a>. The strategic aspects of this renewed relationship will provide Emerald with research funding over the three-year period and the opportunity to receive milestones and royalties on future drug product revenues.</p>
<p>
	&ldquo;The collaborative nature of our relationship with the team at Emerald BioStructures has been instrumental in elucidating multiple targets and identifying promising, novel lead compounds in our discovery programs,&rdquo; commented Dr. Ismail Kola, President, UCB NewMedicines.</p>
<p>
	Emerald will apply its high-throughput crystallography and ligand characterization expertise to provide fragment screening and structural biology support for UCB&rsquo;s severe diseases discovery programs. Emerald and UCB first entered into collaboration in February 2009.</p>
<p>
	&ldquo;It is our mission to enable companies like UCB with structural insights,&rdquo; commented Diana Wetmore, VP of Business Development and Alliances at Emerald BioStructures. &ldquo;We are very excited about moving into this new phase with UCB, expanding our role in the discovery of breakthrough medicines for unmet needs.&rdquo;</p>
<p>
	<strong>Meet Emerald BioStructures at BIOEurope in Dusseldorf, Germany &ndash; October 31-November 2</strong></p>
<p>
	Diana Wetmore, VP of Business Development and Alliances at Emerald BioStructures, will be participating in the partnering forum at <a href="http://www.ebdgroup.com/bioeurope/index.php">BIOEurope in Dusseldorf, Germany</a> and is available for select one-on-one meetings with interested parties.</p>
<p>
	About UCB</p>
<p>
	UCB, Brussels, Belgium (<a href="http://www.ucb.com">http://www.ucb.com</a>) is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. With more than 8 500 people in about 40 countries, the company generated revenue of EUR 3.2 billion in 2010. UCB is listed on Euronext Brussels (symbol: UCB).</p>
<p>
	About Emerald BioStructures</p>
<p>
	Emerald BioStructures is an integrated gene-to-structure contract research organization that provides collaborative drug discovery services to pharmaceutical companies, biotechnology companies, academic institutions, and government facilities. The company operates a high-throughput platform leveraged for fragment-based lead discovery, structure-based drug design, and elucidation of antibody-antigen structures. Emerald&rsquo;s work provides a solid foundation for the discovery of highly selective, efficacious drugs. <a href="http://www.emeraldbiostructures.com">http://www.emeraldbiostructures.com</a></p>
<p>
	Contacts</p>
<p>
	For Emerald BioStructures:<br />
	Diana Wetmore, 206-780-8959<br />
	or<br />
	For Media:<br />
	MacDougall Biomedical Communications<br />
	Jennifer Conrad, 781-235-3060</p>

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	  <dc:date>2011-10-26T12:05:49+00:00</dc:date>
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	  <title>Pieris Selects Emerald BioStructures for Structural Studies of a New Class of Biologics</title>
	  <link>http://www.emeraldbiostructures.com//news/pieris_selects_emerald_biostructures_for_structural_studies_biologic</link>
	  <guid>http://www.emeraldbiostructures.com//news/pieris_selects_emerald_biostructures_for_structural_studies_biologic#When:19:03:00Z</guid>
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	<strong>Bainbridge Island, WA. October 14, 2011.</strong> Pieris AG (Freising, Germany ) has selected Emerald BioStructures, Inc. to resolve the three dimensional structures of bioengineered Anticalin&reg; proteins in complex with target antigen proteins.&nbsp; The structural studies will support Pieris&rsquo; efforts to confirm details of Anticalin-antigen interactions and utilize the information for structure guided design of next generation protein therapeutics.&nbsp; This fee based and milestone project will utilize Emerald&rsquo;s high throughput crystallization platform and biophysical tool set for characterization of protein-protein and antigen-antibody interactions.</p>
<p>
	<strong>About Emerald BioStructures</strong></p>
<p>
	Emerald BioStructures is an integrated gene-to-structure contract research organization that provides collaborative drug discovery services to pharmaceutical companies, biotechnology companies, academic institutions, and government facilities. The company operates a high-throughput platform leveraged for fragment-based lead discovery, structure-based drug design, and elucidation of antibody-antigen structures. Emerald&rsquo;s work provides a solid foundation for the discovery of highly selective, efficacious drugs. <a href="http://www.emeraldbiostructures.com">www.emeraldbiostructures.com</a></p>
<p>
	<strong>About Pieris AG</strong></p>
<p>
	Pieris AG is an independent, clinical-staged biotechnology company advancing its proprietary Anticalin&reg; technology to create safer, more efficacious and more convenient protein therapeutics.&nbsp; Exclusive to Pieris, Anticalin-based drugs promise to address high-unmet medical needs and expand the therapeutic potential of current targeted approaches.&nbsp; Pieris&rsquo; pipeline ranges from its Phase I compound, PRS-050 (anti-VEGF, oncology), to multiple Anticalins in preclinical development. The company has four ongoing discovery and development collaborations: Daiichi Sankyo, Takeda San Francisco, the Sanofi Group and Allergan.&nbsp; Privately held, Pieris has been funded by premier biotechnology-focused venture capital, including lead investors OrbiMed Advisors and Global Life Science Ventures.&nbsp; For more information, please visit: <a href="http://www.pieris-ag.com">www.pieris-ag.com</a>.</p>
<p>
	Emerald BioStructures Contact:<br />
	Emerald BioStructures: Diana Wetmore, VP of Business Development &amp; Alliances (206) 780-8959, <a href="mailto:dwetmore@embios.com">dwetmore@embios.com</a></p>
<p>
	Pieris AG Contact:<br />
	Pieris AG: Laurent Audoly PhD, CSO and Head of Research &amp; Development, <a href="mailto:Audoly@pieris-ag.com">Audoly@pieris-ag.com</a></p>

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	  <dc:date>2011-10-14T19:03:00+00:00</dc:date>
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	  <title>Emerald BioStructures, Deciphera Pharmaceuticals Continue Allosteric Kinase Inhibitor Collaboration</title>
	  <link>http://www.emeraldbiostructures.com//news/emerald_biostructures_deciphera_pharmaceuticals_continue_collaboration_on_a</link>
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	<strong>Bainbridge Island, WA. September 30, 2011.</strong> Deciphera Pharmaceuticals LLC (Lawrence, Kansas) has renewed an agreement with Emerald BioStructures, Inc. to elucidate the X-ray co-crystal structures of novel &ldquo;Switch Pocket Inhibitors&rdquo; bound to kinase targets implicated in tumor growth and autoimmune diseases. Emerald and Deciphera have had a longstanding collaboration which has resulted in the atomic resolution structure determination of more than 100 effectors bound kinase co-crystal structures. This fee based and milestone project will utilize Emerald&rsquo;s Crystal Ready&trade; kinase and high throughput crystallization platforms.</p>
<p>
	<strong>About Emerald BioStructures&nbsp;</strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br />
	Emerald BioStructures is an integrated gene-to-structure contract research organization that provides collaborative drug discovery services to pharmaceutical companies, biotechnology companies, academic institutions, and government facilities. The company operates a high-throughput platform leveraged for fragment-based lead discovery, structure-based drug design, and elucidation of antibody-antigen structures. Emerald&rsquo;s work provides a solid foundation for the discovery of highly selective, efficacious drugs. <a href="http://www.emeraldbiostructures.com">www.emeraldbiostructures.com</a></p>
<p>
	<strong>About Deciphera Pharmaceuticals</strong><br />
	Deciphera Pharmaceuticals, LLC was established in 2003 as a drug discovery and development company with the mission to design, optimize and introduce &ldquo;best-in-class&rdquo; small molecule Switch Inhibitors of protein kinases for human clinical trials and the global pharmaceutical marketplace through the use of its proprietary drug discovery technology platform, Phylomechanics.&nbsp; <a href="http://www.deciphera.com">www.deciphera.com</a></p>
<p>
	Emerald BioStructures Contact:<br />
	Emerald BioStructures: Diana Wetmore, VP of Business Development &amp; Alliances (206) 780-8959, <a href="mailto:dwetmore@embios.com">dwetmore@embios.com</a></p>
<p>
	Deciphera Pharmaceuticals Contact:<br />
	Daniel Flynn, CEO, (785) 830-2100, <a href="mailto:dflynn@deciphera.com">dflynn@deciphera.com</a></p>

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	  <dc:date>2011-09-30T21:49:57+00:00</dc:date>
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	  <title>Emerald BioStructures Initiates Collaboration With Cephalon</title>
	  <link>http://www.emeraldbiostructures.com//news/emerald_biostructures_initiates_collaboration_with_cephalon</link>
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	<strong>Bainbridge Island, WA, September 16, 2011. </strong>Emerald BioStructures, Inc., announces the intiation of a new research collaboration with Cephalon to obtain antibody-antigen co-crystal structures. The milestone based research collaboration provides Cephalon access to Emerald&#39;s rapid high-throughput crystallization platform and Emerald&#39;s biophysical tool set for characterization of protein-protein interactions.</p>
<p>
	<strong>About Emerald BioStructures:</strong></p>
<p>
	Emerald BioStructures is an integrated gene-to-structure contract research organization that provides collaborative drug discovery services to pharmaceutical companies, biotechnology companies, academic institutions, and government facilities. The company operates a high-throughput platform leveraged for fragment-based lead discovery and structure-based drug design. Emerald&#39;s work provides a solid foundation for the discovery of highly selective, efficacious drugs. <a href="http://www.emeraldbiostructures.com">www.emeraldbiostructures.com</a></p>

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	  <dc:date>2011-09-16T18:29:45+00:00</dc:date>
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	  <title>SSGCID Collaborative Structural Genomics Project Creates Infectious Disease, Biodefense Blueprint</title>
	  <link>http://www.emeraldbiostructures.com//news/ssgcid_collaborative_structural_genomics_project_creates_infectious_disease</link>
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	<strong>Special Journal Edition Chronicles 3D Structures of Important Antibacterial and Bioterrorist Targets</strong></p>
<p>
	SEATTLE, WA--(Marketwire - September 1, 2011) - The September issue of the online scientific journal <em>Acta Crystallographica: Structural Biology and Crystallization Communications</em> <em>(</em><em>Acta Cryst F) </em>will consist entirely of work done at the Seattle Structural Genomics Center for Infectious Disease (SSGCID), a consortium of researchers from Seattle BioMed, Emerald BioStructures, the University of Washington and Pacific Northwest National Laboratory (PNNL). This free online edition (found at <a href="http://journals.iucr.org/f/issues/2011/09/00/issconts.html">http://journals.iucr.org/f/issues/2011/09/00/issconts.html</a>) features 30 peer-reviewed manuscripts, describing 40 unique infectious disease protein structures, as well as high-throughput gene-to-structure methodologies developed by SSGCID, and marks only the second time that <em>Acta Cryst F</em> has dedicated an entire issue to a single Structural Genomics center.&nbsp;The elucidation of such a large number of protein structures by the SSGCID consortium, all of which are freely available to scientific researchers to study and compare, provides a highly detailed "blueprint" for fighting infectious disease and bioterrorism.</p>
<p>
	Funded in late 2007 by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), to determine the three-dimensional structures of proteins from biodefense organisms and emerging infectious diseases; the SSCGID is directed by Dr. Peter Myler, a Full Member at Seattle BioMed and principal investigator of the project.&nbsp;"Currently the SSCGID has solved more than 375 protein structures from pathogenic microbes, providing much-needed new knowledge that serves as a starting point for structure-based drug design," said Myler.&nbsp;Many SSGCID structures also contain information on how small molecules bind to infectious disease proteins, providing highly valuable information for a drug discovery and development.&nbsp;Lance Stewart, CEO of Emerald BioStructures and co-principal investigator of the SSGCID project, commented "We&#39;ve worked together to create an environment that combines the best of academia and industry.&nbsp;Instead of competing on infectious disease targets and drug compounds as traditional pharma or biotech companies do, we are building a shared knowledge base aimed at addressing important unmet needs."</p>
<p>
	The manuscripts featured in <em>Acta Cryst F</em> discuss potential drug-targets from organisms that cause some of the world&#39;s deadliest diseases, including emerging pathogens and possible bioterror agents.&nbsp;One paper in the September edition features new insight into an iron-binding protein (called rubredoxin) from <em>Mycobacterium tuberculosis,</em> the bacterium that causes tuberculosis (TB), a disease which is responsible for nearly two million deaths annually.&nbsp;The new understanding of the protein&#39;s biological function revealed by this structure may speed up the development of new drug therapies urgently needed to prevent TB epidemics due to the recent emergence of multi drug-resistant (MDR) and extremely drug-resistant (XDR) strains.&nbsp;<em>Coccidioides immitis</em>, a lesser-known organism featured in the SSGCID special edition, causes coccidioidomycisis or "Valley Fever" in the southwestern U.S.&nbsp;This sometimes-fatal disease can be contracted when a person breathes fungal spores from dust or dirt that has been disturbed by wind, and can cause fever, chest pain and coughing, among other more severe symptoms.&nbsp;The genome of <em>C. immitis </em>was sequenced recently, but very few of its proteins have been structurally characterized.&nbsp;The structures solved by SSGCID will increase the understanding of important enzymes involved in detoxification and nucleotide biosynthesis/salvage within this pathogenic fungus.</p>
<p>
	According to Myler, scientists from the SSCGID and its sister organization, the Center for Structural Genomics of Infectious Diseases (CSGID), which is led by Dr. Wayne Anderson of the Northwestern University Feinberg School of Medicine, gathered in Seattle in early August to review structures solved to date and determine priorities for the next year. "Between the two centers, we will solve over 1,000 structures by the end of 2012," said Myler.&nbsp;"With new information that is shared immediately through the NIH-supported Protein Data Bank (<a href="http://www.pdb.org">www.pdb.org</a>), we are providing critical starting points for discovery and development of novel drugs, vaccines and diagnostics for a wide range of infectious diseases."</p>
<p>
	<strong>ABOUT SEATTLE BIOMEDICAL RESEARCH INSTITUTE:</strong><br />
	Seattle BioMed is the largest independent, non-profit organization in the U.S. focused solely on infectious disease research.&nbsp;Our research is the foundation for new drugs, vaccines and diagnostics that benefit those who need our help most: the 14 million who will otherwise die each year from infectious diseases, including malaria, HIV/AIDS and tuberculosis. Founded in 1976, Seattle BioMed has more than 360 staff members.&nbsp;By partnering with key collaborators around the globe, we strive to make discoveries that will save lives sooner.&nbsp;For more information, visit <a href="http://www.seattlebiomed.org">www.seattlebiomed.org</a>.</p>
<p>
	<strong>ABOUT EMERALD BIOSTRUCTURES:</strong><br />
	Emerald BioStructures is an integrated gene-to-structure contract research organization (CRO) that provides collaborative drug discovery services to pharmaceutical companies, biotechnology companies, academic institutions, and government facilities.&nbsp;The company operates a high-throughput platform leveraged for fragment-based lead discovery and structure-based drug design.&nbsp;Emerald&#39;s work provides a solid foundation for the discovery of highly selective, efficacious drugs.&nbsp;Learn more at <a href="http://www.emeraldbiostructures.com">www.emeraldbiostructures.com</a>.</p>

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	  <dc:date>2011-09-01T14:00:13+00:00</dc:date>
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	  <title>Emerald BioStructures’ Structural Biology Expertise Supports Advancement of 3 New Drug Candidates</title>
	  <link>http://www.emeraldbiostructures.com//news/emerald_biostructures_structural_biology_expertise_supports_advancement_of</link>
	  <guid>http://www.emeraldbiostructures.com//news/emerald_biostructures_structural_biology_expertise_supports_advancement_of#When:13:33:20Z</guid>
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	Full Title:&nbsp;Emerald BioStructures&rsquo; Structural Biology Expertise Supports Advancement of Three New Drug Candidates</p>
<p>
	<a href="/images/uploads/News_Emerald BioStructures_Three_Drug_Candidates.pdf" onclick="window.open(this.href, '', 'resizable=no,status=no,location=no,toolbar=no,menubar=no,fullscreen=no,scrollbars=no,dependent=no,width=960,height=680'); return false;">Download a PDF of this Press Release</a></p>
<p>
	<strong>Bainbridge Island WA, June 7, 2011&mdash;</strong> Emerald BioStructures, a leading provider of integrated structural biology services, today announced that protein crystal structures determined at Emerald BioStructures have supported the advancement of three drug candidates to clinical trials, for leukemia, asthma, and spinal muscular atrophy. This milestone brings the total count of Emerald&rsquo;s collaborator INDs (investigational new drugs) to eight, with six of these in clinical trials, and makes Emerald BioStructures one of the most prolific structure-based drug design contract service organizations in the world.</p>
<p>
	Targeted drug design enables the progress of the most promising candidates for clinical development and increases chances of clinical success because it reveals molecules with desirable properties, such as high solubility, low molecular weight, and other drug-like qualities. &ldquo;The Emerald team congratulates our colleagues at Deciphera, N30, and Families of Spinal Muscular Atrophy and its development partner RepliGen for their tremendous achievements to bring breakthrough new drug candidates into clinical trials.&nbsp; We feel privileged to have had the opportunity to provide high resolution structural insight to guide the development of these clinical-stage drug candidates,&rdquo; said Lance Stewart, CEO of Emerald BioStructures.</p>
<p>
	The three drug candidates include: DCC-2036, being developed for the treatment of a resistant form of leukemia and in trials sponsored by Deciphera Pharmaceuticals and researchers at Tufts Medical Center, M.D. Anderson, and the University of Michigan; N6022, being developed for the treatment of asthma and in trials sponsored by N30 Pharmaceuticals LLC; and RG3039, being developed for the treatment of spinal muscular atrophy and in trials sponsored by RepliGen Corporation in cooperation with Families of Spinal Muscular Atrophy. &nbsp;</p>
<p>
	<img alt="" src="/images/uploads/n30-logo-web.gif" style="border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; margin-left: 5px; margin-right: 5px; margin-top: 5px; margin-bottom: 5px; float: left; width: 128px; height: 110px; " />"The power in designing drugs based on structures of biological targets is that we&rsquo;re able to rapidly discover novel therapies that affect the molecular mechanisms responsible&nbsp;for the disorder,&rdquo; said Gary Rosenthal, Ph.D, Executive Vice President Research at N30 Pharmaceuticals. Their investigational new drug is the first GSNOR inhibitor to enter human clinical development. The March 2011 issue of American Chemical Society Medicinal Chemistry Letters documents this work in a paper titled, &ldquo;<a href="http://pubs.acs.org/doi/abs/10.1021/ml200045s">Discovery of S-Nitrosoglutathione Reductase Inhibitors: Potential Agents for the Treatment of Asthma and Other Inflammatory Diseases</a>.&rdquo;</p>
<p>
	<img alt="" src="/images/uploads/deciphera=logo.jpg" style="border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; margin-left: 5px; margin-right: 5px; margin-top: 5px; margin-bottom: 5px; float: right; width: 176px; height: 108px; " />&ldquo;The molecular targeting performed at Emerald allowed us to tailor our drug candidate DCC-2036 to the specific mutation that causes resistance to traditional therapies for this type of leukemia,&rdquo; said Daniel Flynn, CEO of Deciphera. &ldquo;Structure-based drug design is promising in its efficiency and Emerald offers best-in-class structural biology services.&rdquo; The Deciphera drug candidate is being developed to treat individuals with leukemia who have developed a mutant enzyme that leads to a relapse that is resistant to all currently marketed therapies. DCC-2036 blocks this mutation at the molecular level. &nbsp;The work is documented in a paper titled, &ldquo;<a href="http://www.cell.com/cancer-cell/abstract/S1535-6108(11)00092-4?switch=standard">Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036</a>&rdquo; in the April 2011 issue of the publication Cancer Cell.</p>
<p>
	<img alt="" src="/images/uploads/families-of-sma-LOGO.jpg" style="border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-top-style: solid; border-right-style: solid; border-bottom-style: solid; border-left-style: solid; margin-left: 5px; margin-right: 5px; margin-top: 5px; margin-bottom: 5px; float: left; width: 200px; height: 107px; " />&ldquo;Emerald&rsquo;s structural insights helped us to identify an important target called &lsquo;DcpS&lsquo; which plays a role in gene expression.&nbsp; Our drug candidate inhibits DcpS and improves the activity of a key gene involved in spinal muscular atrophy,&rdquo; said Jill Jarecki, Ph.D., Research Director of Families of SMA.&nbsp; This drug candidate has the potential to treat SMA, which is a genetic disorder affecting about 1 in 6,000 births per year and is the leading genetic cause of death in children under the age of two. Emerald&rsquo;s work on this program is documented in the peer-reviewed paper,&ldquo;<a href="http://www.ncbi.nlm.nih.gov/pubmed/18839960">DcpS as a therapeutic target for spinal muscular atrophy</a>.&rdquo;</p>
<p>
	<strong>About Emerald BioStructures&rsquo; Structure-based Drug Design</strong></p>
<p>
	The lead discovery program at Emerald BioStructures generates drug-like compounds via a high-throughput pipeline for rapidly generating ligand-protein co-crystal X-ray structures.&nbsp; The process integrates X-ray crystallography, NMR, SPR, and computational modeling to the clients&rsquo; target proteins and small molecule ligands.Emerald&rsquo;sstructural data and collaborative approach have proven to be extremely valuable in helping our clients identify successful drug candidates.</p>
<p>
	<strong>About Emerald BioStructures&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </strong></p>
<p>
	Emerald BioStructures is an integrated gene-to-structure contract research organization that provides collaborative drug discovery services to pharmaceutical companies, biotechnology companies, academic institutions, and government facilities. The company operates a high-throughput platform leveraged for fragment-based lead discovery and structure-based drug design. Emerald&rsquo;s work provides a solid foundation for the discovery of highly selective, efficacious drugs. <a href="http://www.emeraldbiostructures.com/">www.emeraldbiostructures.com</a></p>
<p>
	<strong>About Deciphera Pharmaceuticals</strong></p>
<p>
	Deciphera Pharmaceuticals, LLC was established in 2003 as a drug discovery and development company with the mission to design, optimize and introduce &ldquo;best-in-class&rdquo; small molecule Switch Inhibitors of protein kinases for human clinical trials and the global pharmaceutical marketplace through the use of its proprietary drug discovery technology platform, Phylomechanics.&nbsp; <a href="http://www.deciphera.com/">www.deciphera.com</a>&nbsp; &nbsp;</p>
<p>
	<strong>About N30 Pharmaceuticals</strong></p>
<p>
	N30 Pharma is a privately held biopharmaceutical company headquartered in&nbsp;Boulder, Colorado. &nbsp;N30 Pharma focuses on the discovery and development of proprietary drugs that provide therapeutic advantage over current treatment for major human diseases such as asthma, COPD and IBD. The Company&#39;s strategy is to focus upon discovery research and early-stage clinical development, and then establish one or more partnerships with leading pharmaceutical companies to further the advancement of its lead clinical candidates. <a href="http://www.n30pharma.com/">www.n30pharma.com</a></p>
<p>
	<strong>About Families of Spinal Muscular Atrophy</strong></p>
<p>
	Families of SMA is a non-profit 501(c)3 tax exempt organization with 30 Chapters throughout the United States and over 70,000 members and supporters.&nbsp; Families of SMA funds and directs the leading SMA research programs.&nbsp; The successful results and progress from basic research to drug discovery programs to clinical trials provide real hope for families and patients. <a href="http://www.curesma.org/">www.curesma.org</a></p>
<p>
	<strong>Contact:</strong></p>
<p>
	<strong>For Emerald BioStructures:</strong></p>
<p>
	Lance Stewart, CEO</p>
<p>
	(206) 780-8911</p>
<p>
	<a href="mailto:lstewart@embios.com">lstewart@embios.com</a></p>
<p>
	<strong>For Media:</strong></p>
<p>
	Douglas MacDougall or Jennifer Conrad</p>
<p>
	MacDougall Biomedical Communications</p>
<p>
	(781) 235-3060</p>

	  ]]></description> 
	  <dc:subject></dc:subject>
	  <dc:date>2011-06-07T13:33:20+00:00</dc:date>
	</item>

	<item>
	  <title>Emerald signs crystallography initiative with Pharmasset, Inc.</title>
	  <link>http://www.emeraldbiostructures.com//news/emerald_signs_crystallography_initiative_with_pharmasset_inc</link>
	  <guid>http://www.emeraldbiostructures.com//news/emerald_signs_crystallography_initiative_with_pharmasset_inc#When:05:02:50Z</guid>
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				<img src="/images/uploads/Pharmasset_Logo1_thumb.jpg" alt="" />
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		<p>
	<a href="/images/uploads/News-Emerald signs crystallography initiative with Pharmasset.pdf" onclick="window.open(this.href, '', 'resizable=no,status=no,location=no,toolbar=no,menubar=no,fullscreen=no,scrollbars=no,dependent=no,width=960,height=680'); return false;">Download a PDF of this News Annoucement</a></p>
<p>
	<strong>Bainbridge Island, WA. February 15th, 2011.</strong> Emerald BioStructures has initiated a crystallography initiative with Pharmasset, Inc.&nbsp; The goal of the milestone-based project is to crystallize a novel macromolecular complex that has not been previously described.&nbsp; The collaboration provides Pharmasset access to Emerald&rsquo;s high throughput protein crystallization pipeline and expertise in protein engineering and solving <em>de novo</em> X-ray crystal structures. &ldquo;After evaluating several vendors, we chose to collaborate with Emerald because of the quality of scientists working there and their proven ability to crystallize and solve novel and difficult structures similar to those of interest to our research team,&rdquo; said Ralph Mosley, Head of Computational Chemistry at Pharmasset.</p>
<p>
	&ldquo;We are excited about the opportunity to potentially provide additional insight into the mode of action of Pharmasset&rsquo;s exciting compounds and enhance their medicinal chemistry and discovery efforts,&rdquo; said Lance Stewart, CEO Emerald BioStructures.</p>
<p>
	<strong>About Emerald BioStructures:</strong></p>
<p>
	Emerald BioStructures is an integrated gene-to-structure collaborative research organization specializing in drug discovery services. Emerald operates an efficient high-throughput platform leveraged for fragment-based lead discovery and structure-based drug design. We provide enabling structural insight for breakthrough drugs that are highly selective and efficacious against chosen targets.</p>
<p>
	<strong>About Pharmasset </strong></p>
<p>
	Pharmasset is a clinical-stage pharmaceutical company committed to discovering, developing, and commercializing novel drugs to treat viral infections. Pharmasset&#39;s primary focus is on the development of oral therapeutics for the treatment of hepatitis C virus (HCV). The company&rsquo;s research and development efforts focus on nucleoside/tide analogs, a class of compounds which act as alternative substrates for the viral polymerase, thus inhibiting viral replication. We currently have three clinical-stage product candidates. RG7128, a cytosine nucleoside analog for chronic HCV infection, is in two Phase 2b clinical studies in combination with Pegasys&reg; plus Copegus&reg; and is also in the INFORM studies, the first series of studies designed to assess the potential of combinations of small molecules without Pegasys&reg; and Copegus&reg; to treat chronic HCV. These clinical studies are being conducted through a strategic collaboration with Roche. Our other clinical stage HCV candidates include PSI-7977, an unpartnered uracil nucleotide analog that is currently dosing in two phase Phase 2b studies in patients with HCV genotypes 1, 2, or 3, and PSI-938, an unpartnered guanosine nucleotide analog which recently completed a 14-day monotherapy study and has recently initiated a 14-day combination study with PSI-7977. We also have in our pipeline an additional purine nucleotide analog, PSI-661, in advanced preclinical development.</p>
<p>
	<strong>Pharmasset Forward-Looking Statement</strong></p>
<p>
	Pharmasset&nbsp;"Safe Harbor" Statement under the Private Securities Litigation Reform Act of 1995:&nbsp;Statements in this press release that are not historical facts are "forward-looking statements," that involve risks, uncertainties, and other important factors, including, without limitation,&nbsp;the risk of cessation or delay of any of the ongoing or planned clinical trials and/or our development of our product candidates,&nbsp;the risk that the results of previously conducted studies involving our product candidates will not be repeated or observed in ongoing or future studies involving our product candidates, the risk that our collaboration with&nbsp;Roche&nbsp;will not continue or will not be successful, and the risk that any one or more of our product candidates will not be successfully developed and commercialized.&nbsp;For a discussion of risks, uncertainties, and other important factors, any of which could cause our actual results to differ from those contained in the forward-looking statements, see the section entitled "Risk Factors" in our Annual Report on Form 10-K for the fiscal year ended&nbsp;September 30, 2010&nbsp;filed with the&nbsp;Securities and Exchange Commission&nbsp;and discussions of potential risks, uncertainties, and other important factors in our subsequent filings with the&nbsp;Securities and Exchange Commission.</p>
<p>
	<strong>Contact:</strong></p>
<p>
	Emerald BioStructures:<br />
	Lance Stewart, CEO<br />
	(206) 780-8911<a href="mailto:lstewart@embios.com"><br />
	<a href="mailto:lstewart@embios.com">lstewart@embios.com</a></a></p>

	  ]]></description> 
	  <dc:subject></dc:subject>
	  <dc:date>2011-02-15T05:02:50+00:00</dc:date>
	</item>

	<item>
	  <title>Emerald BioStructures Achieves Second Milestone and Expands Collaboration with UCB</title>
	  <link>http://www.emeraldbiostructures.com//news/emerald_biostructures_achieves_second_milestone_and_expands_collaboration_w</link>
	  <guid>http://www.emeraldbiostructures.com//news/emerald_biostructures_achieves_second_milestone_and_expands_collaboration_w#When:12:00:24Z</guid>
	  <description><![CDATA[
		  
		<p>
	<a href="/images/uploads/News-Emerald_Achieves_Second_Milestone_with_UCB.pdf" onclick="window.open(this.href, '', 'resizable=no,status=no,location=no,toolbar=no,menubar=no,fullscreen=no,scrollbars=no,dependent=no,width=960,height=680'); return false;">Download a PDF of this News Announcement</a></p>
<p>
	<strong>Emerald and UCB Expand Collaborative Work in Fragment-Based Drug Discovery, Targeting the Development of Small Molecule Antagonists </strong></p>
<p>
	&nbsp;</p>
<p>
	BAINBRIDGE ISLAND, WA. January 7, 2011. Emerald BioStructures, a leading provider of fragment-based drug discovery services, announced today that it has successfully achieved the second milestone in its collaboration with UCB on the structure-based discovery of small molecule modulators of undisclosed targets.&nbsp;</p>
<p>
	&nbsp;</p>
<p>
	Working in close collaboration, the team of researchers at Emerald and UCB have solved high-resolution X-ray crystallographic structures of multiple targets, and have identified unique lead series of small molecules.&nbsp; These molecules were designed based on enabling structural insights of fragment hit molecules previously obtained within the collaboration.</p>
<p>
	&nbsp;</p>
<p>
	&ldquo;Emerald and UCB initiated their collaboration partnership in January of 2009, and over the last 24 months, have made significant progress,&rdquo; said Neil Weir, Sr. VP of Research at UCB.&nbsp; &ldquo;We are very impressed with Emerald&rsquo;s ability to consistently deliver structural insights in a fast-paced and exciting project that requires continuous innovation.&rdquo;&nbsp;</p>
<p>
	&nbsp;</p>
<p>
	&ldquo;In this collaborative effort, we&rsquo;ve identified multiple modulators of protein structure and function,&rdquo; said Alex Burgin, COO of Emerald BioStructures. &ldquo;We look forward to supporting UCB in their structure-guided design and selection of clinical candidates over the next 24 months.&rdquo;</p>
<p>
	&nbsp;</p>
<p>
	In addition, Emerald and UCB have expanded their collaboration in structure-based drug discovery. &ldquo;The expansion of our UCB collaboration is an important demonstration of the confidence that UCB has in the Emerald team, and is a clear validation of our fragment-based X-ray structure technology, especially when applied to challenging targets,&rdquo; said Lance Stewart, CEO of Emerald BioStructures. The financial terms of the research fee, milestone and royalty-bearing relationship were not disclosed; however, the project supports multiple full-time researcher equivalents at Emerald.</p>
<p>
	&nbsp;</p>
<p>
	<strong>About Emerald BioStructures: </strong></p>
<p>
	Emerald BioStructures is an integrated gene-to-structure collaborative research organization specializing in drug discovery services. Emerald operates an efficient high-throughput platform leveraged for fragment-based lead discovery and structure-based drug design.&nbsp; Our scientists provide enabling structural insight for breakthrough drugs that are highly selective and efficacious against chosen targets.</p>
<p>
	&nbsp;</p>
<p>
	<strong>About UCB:</strong></p>
<p>
	UCB, Brussels, Belgium (<a href="http://www.ucb.com" onclick="window.open(this.href, '', 'resizable=no,status=no,location=no,toolbar=no,menubar=no,fullscreen=no,scrollbars=no,dependent=no,width=960,height=680'); return false;">www.ucb.com</a>) is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. With more than 8 000 people in about 40 countries, the company generated revenue of EUR 3.1 billion in 2009. UCB is listed on Euronext Brussels (symbol: UCB).</p>
<p>
	&nbsp;</p>
<p>
	<strong>Contact:</strong></p>
<p>
	<strong>For Emerald BioStructures:</strong></p>
<p>
	Lance Stewart, CEO</p>
<p>
	(206) 780-8911</p>
<p>
	<a href="mailto:lstewart@embios.com?subject=Email%20from%20UCB%20Press%20Release"><a href="mailto:lstewart@embios.com">lstewart@embios.com</a></a></p>
<p>
	&nbsp;</p>
<p>
	<strong>For UCB:&nbsp;</strong></p>
<p>
	Nancy Nackaerts, External Communications, UCB<br />
	+32.473.864.414</p>
<p>
	<a href="mailto:nancy.nackaerts@ucb.com">nancy.nackaerts@ucb.com</a></p>
<p>
	&nbsp;</p>
<p>
	<strong>For Media:</strong></p>
<p>
	Douglas MacDougall or Jennifer Conrad</p>
<p>
	MacDougall Biomedical Communications</p>
<p>
	(781) 235-3060</p>
<p>
	&nbsp;</p>

	  ]]></description> 
	  <dc:subject></dc:subject>
	  <dc:date>2011-01-07T12:00:24+00:00</dc:date>
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