Crystal Ready™

Crystal Ready™

Get insights from co-crystal structures with your own ligands through our rapid and cost effective Crystal Ready™ program. Ligand-bound protein crystal structures provide valuable insights to guide medicinal chemistry. Our Crystal Ready™ service includes a gallery of more than 200 crystallized targets, all available for rapid and affordable co-crystallization with your ligand of interest. The service is cost effective and provides structures in a fraction of the time because we work with your ligand in structures we’ve solved before.

The insights of three-dimensional ligand-bound crystal structures can benefit any medicinal chemistry program. Crystal Ready™ saves you money and time so you can focus on designing new molecules.

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Kinase Targets

Abl (wt)-kinase domain

Abl (T315I)-kinase domain

AKT2 (PKB)

bRaf (V600E) NEW

Choline Kinase Alpha NEW

Cyclin dependent kinase 2

Cyclin dependent kinase 4 (mimic)

Glucokinase

GSK3β (- PO4 )

GSK3β (+ PO4)

EGFR (Her kinase)

Hexokinase II NEW

Heme-regulated inhibitor kinase (HRI)

JNK3

KDR (VEGFR2)

cKit-wt

MAP2K2 (MEKK2)

MK2 (MEKK1)

cMet

P38α(- PO4)

P38α(+ PO4)

PDHK4 NEW

PI3Kgamma

Syk

Tankyrase 1 NEW

Tie2

Other Targets

Caspase 2

Caspase 6

Cathepsin S

DcpS

Factor Xa

GSNOR NEW

Glutathione-S transferase 1 NEW

HCV Helicase (NS3)

HCV Polymerase (NS5b)

HCV Protease (NS3/4a)

HCV NS5a Domain I

HDAC4

HRas-wt NEW

HRas- G12D NEW

HSP90

Kallikrein-1

LpxC

LTA4H

NAMPT NEW

PDE1B NEW

PDE4B (Cat.)

PDE4D (Cat.)

PHD2

PHGDH NEW

PPARgamma

Phosphoserine Aminotransferase 1 NEW

Phosphoserine Phosphatase NEW

PTP1B

Recombinase A NEW

RNAaseL NEW

Serine Dehydratase NEW

SPLY1

Thrombin

Infectious Disease Targets

3-oxoacyl-(acyl carrier protein) synthase II, 3E60

2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase , 3MBM

2-dehydro-3-deoxyphosphooctonate aldolase , 3FS2

3-ketoacyl-(acyl-carrier-protein), 3LLS

3-ketoacyl-(acyl-carrier-protein) reductase, 3F9I

3-methyl-2-oxobutanoate hydroxymethyltransferase, 3EZ4

3-oxoacyl-(acyl carrier protein) synthase II, 3KZU

3-oxoacyl-(acyl-carrier-protein) synthase III, 3GWA

6-phosphogluconolactonase, 3ICO

7-alpha-hydroxysteroid dehydrogenase, 3GAF

acetoacetyl-CoA reductase, 3GK3

acetylpolyamine aminohydrolase, 3MEN

acyl carrier protein, 2KWL

acyl-carrier-protein S-malonyltransferase, 3EZO

adenylate kinase, 3GMT

alanine racemase , 3KW3

alcohol dehydrogenase, 3MEQ

Aldehyde dehydrogenase, 3EK1

aldose reductase, 3KRB

Amino acid-binding ACT:D-isomer specific 2-hydroxyacid dehydrogenase, 3K5P

arginine/ornithine transport system ATPase, 3MD0

arsenate reductase (ArsC) related protein, 2KOK

Bacterioferritin, 3FVB

Beta-ketoacyl synthase, 3LRF

beta-lactamase-like protein, 3MD7

cytidine deaminase, 3DMO

cytoplasmic aspartate aminotransferase, 3MEB

deoxyribose phosphate aldolase, 3NDO

deoxyuridine 5-triphosphate nucleotidohydrolase, 3LQW

dihydrodipicolinate reductase, 3IJP

Dihydrofolate reductase/thymidylate synthase, 3I3R

DNA PolC, 3F2B

enoyl-(acyl carrier protein) reductase, 3EK2

enoyl-CoA hydratase, 3H81

Eoxycytidine triphosphate deaminase, 3KM3

Extragenic suppressor protein suhB, 3LUZ

Ferritin:DNA-binding protein Dps, 3GE4

fructose bisphosphate aldolase, 3MBD

fructose-1,6-bisphosphate aldolase, 3KX6

fumarate hydratase, 3GTD

glucosamine-6-phosphate deaminase, 3HN6

Glucose/ribitol dehydrogenase, 3EMK

Glutaredoxin, 2KLX

glutaryl-CoA dehydrogenase, 3D6B

glyceraldehyde 3-phosphate dehydrogenase (gap), 3HJA

glycine cleavage system protein H, 3HGB

Glycine cleavage system protein t, 3GIR

Guanylate Kinase, 3LNC

HAD-superfamily hydrolase, subfamily IA, variant 1, 3KZX

HCV NS3 (Helicase), 3KQH

HCV NS3/4a (Protease), 2XCF

HCV NS5A, 3FQQ

HCV NS5b (Polymerase), 3HKW

Hep_Hag family / Haemagluttinin family protein xadA, 3LAA

hexapeptide transferase family protein, 3IXC

Hit-like protein involved in cell-cycle regulation, 3LB5

hydrolase TatD family protein, 3IPW

inorganic pyrophosphatase, 3D53

Iron superoxide dismutase , 3JS4

Isocitrate dehydrogenase, 3DMS

isocitrate lyase, 3E5B

isoprenoid biosynthesis protein with amidotransferase-like domain, 3L3B

Kinase, CMGC CDK, 3GBZ

Large c-terminal domain of PB2, 3KC6

LpxC, 2VES

macrophage binding protein, 3N7T

malate dehydrogenase, 3D5T

malonyl CoA-acyl carrier protein transacylase, 3G87

methionine aminopeptidase, 3MR1

methionine aminopeptidase, 3MX6

methionine-R-sulfoxide reductase, 3CEZ

methionine-R-sulfoxide reductase, 3CXK

methylcitrate synthase, 3HWK

methylisocitrate lyase, 3EOO

MetRS, 3H9C

mutator mutt, 3HHJ

NAD+ synthase, 3DPI

N-ethylmaleimide reductase, 3GKA

nicotinate-nucleotide pyrophosphorylase, 3GNN

Nucleoside diphosphate kinase family protein, 3JS9

O-siccinylhomoserine sulfhydrylase, 3NDN

Pantoate-beta-alanine ligase:Cytidyltransferase-related domain, 3INN

peptidyl-prolyl cis-trans isomerase, 2KE0

Periplasmic domain of the risS sensor protein, low pH native structure, 3LR3

PFE0790c hypothetical protein, conserved, 2KDN

phosphoglycerate mutase, 3EZN

Phosphoglyceromutase, 3LNT

phosphopantetheine adenylyltransferase, 3IKZ

phosphoribosylamine-glycine ligase, 3LP8

phosphoribosylaminoimidazole-succinocarboxamide synthase, 3KRE

phosphoribosylglycinamide formyltransferase, 3KCQ

Plasmid partition protein, 3K9G

Possible Dehydrogenase, 3KHP

Precorrin-8X methylmutase CbiC/CobH, 3E7D

probable enoyl-CoA hydratase, 3MOY

probable short-chain type dehydrogenase/reductase, 3GVC

PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2, 3HWI

PROBABLE THIOSULFATE SULFURTRANSFERASE SSEA, 3HZU

Protein Rv0543c, 2KVC

protein tyrosine phosphatase, 3ILY

Putative conserved protein mbtH,2KHR

putative diphthine synthase,3I4T

Putative endoribonuclease L-PSP, 3M1X

putative glutathione transferase, 3LG6

pyridoxal phosphate biosynthetic protein, 3GK0

RecA, 1XMV

ribose-5-phosphate isomerase, 3HHE

ribose-phosphate pyrophosphokinase, 3DAH

RNA methyltransferase, TrmH, 3E5Y

Rubredoxin, 2KN9

S adenosyl-L-homocysteine hydrolase, 3N58

SAM synthase, 3IML

serine hydroxymethyltransferase, 3ECD

Short-chain dehydrogenase/reductase SDR:Glucose/ribitol dehydrogenase, 3GRK

single-stranded binding protein, 3LGJ

succinate-semialdehyde dehydrogenase (NADP+), 3IFG

tetrahydropyridine 2-carboxylate N-succinyl transferase, 3EG4

Thymidylate Kinase, 3LD9

Thymidylate synthase (EC 2.1.1.45) thyA, 3IX6

Thymidylate synthase 1/2 TS-1, 3KGB

Thymidylate Synthase X, 3GWC

transcriptional cofactor/pterin hydratase, 3JST

triosephosphate isomerase , 3GVG

TrkA glyceraldehyde-3-phosphate dehydrogenase, 3DOC

tRNA (guanine-n1)-methyltransferase, 3IEF

UDP-glucose 4 epimerase, 3ENK

uracil phosphoribosyltransferase, 3DMP