Antibody-Antigen and Protein-Nucleic Acid Complexes for X-Ray Crystallography
Date: Feb 21, 2012
Time: 11:00 – 11:50 AM PDT
Speaker: Alex Burgin, Ph.D. Chief Operating Officer, Emerald BioStructures, and Doug Davies, Ph.D., Senior Project Leader, Emerald BioStructures
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Many biological macromolecules derive their function from interactions with other macromolecules. Understanding these interactions is crucial for developing therapeutics. Emerald BioStructures is a structural biology Contract Research Organization with extensive experience in elucidating macromolecular complexes including antibody-antigen and protein-nucleic acid complexes. In this Webinar, Emerald scientists will discuss some of the practical issues involved in preparing macromolecular complexes for crystallization and X-ray diffraction experiments. For antibody complexes, issues of Fab preparation, complex formation and analysis will be discussed. Protein-nucleic acid complex formation will be discussed with an emphasis on sourcing and optimizing oligonucleotides for crystallization, with numerous case studies included. This webinar should be of interest to X-ray crystallographers and researchers looking to collaborate with X-ray crystallographers to solve novel macromolecular complex structures.